๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Protection and selection for gene therapy in the hematopoietic system

โœ Scribed by Michael D. Milsom; Leslie J. Fairbairn

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
189 KB
Volume
6
Category
Article
ISSN
1099-498X

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โœฆ Synopsis

Hematopoietic stem cell gene therapy is potentially curative for a number of inherited and acquired disorders. However, poor gene transfer and expression in repopulating hematopoietic stem cells attenuate this potential. Here we review potential means of conferring a selective advantage to hematopoietic stem cells and their progeny, and discuss the issues that surround the use of selective advantages in vivo.

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