✦ LIBER ✦

Gene therapy in the central nervous system: Direct versus indirect gene delivery

✍ Scribed by J.-L. Ridet; A. Privat

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 733 KB
Volume: 42
Category: Article
ISSN: 0360-4012
DOI: 10.1002/jnr.490420302

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Over the last decade, the combination of molecular biology and cell transplantation techniques has given rise to a powerful method for gene therapy. The implantation of genetically modified cultured cells has been extensively used in the central nervous system (CNS) in various experimental models of neurologic disorders. More recently, viral and chemical methods have been developed to further efforts to shuttle transgenes into the relatively inaccessible brain. Adenoviral and liposomal synthetic vectors carry transgenes into neural tissue in situ and are beginning to show promise as new methods for CNS therapy. © 1995 Wiley‐Liss, Inc.

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