P-Glycoprotein (PGP), a product of the multidrug resistance gene (mdr), acts as an adenosine triphosphate-dependent drug efflux system in cells. Initially, PGP was found in cancer cells, but it is now known that PGP is richly distributed in the adult brain. Passage to the central nervous system is l
Increased expression of the multidrug-resistance gene in undifferentiated sarcoma
โ Scribed by Akio Tawa; Masami Inoue; Shigehiko Ishihara; Junichi Hara; Keiko Yumura-Yagi; Kenzo Okumura; Akira Okada; Akio Nihei; Junji Taguchi; Nobuhiro Kanai; Takashi Tsuruo; Keisei Kawa-Ha
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 497 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
BACKGROUND. Multidrug resistance protein (MRP) is a membrane
Multidrug resistance (MDR) in human cancer is often associated with over-expression of the mdr-1 gene, which encodes a 170-kDa transmembrane protein, termed P-glycoprotein (P-gp). We evaluated the immunoreactivity of P-gp in oral tissues at different stages of tumorigenesis in the Indian population
## BACKGROUND. Epithelioid sarcoma is a highly malignant soft tissue tumor that is largely resistant to conventional chemotherapy and radiotherapy. Because paclitaxel has been proven to be effective in other human malignancies refractory to conventional chemotherapy, the authors analyzed the in vit