𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The modified nucleosides from the “ wobble position ” of tRNAs. The synthesis of 5-carboxymethylaminomethyluridine and 5-carboxymethylaminomethyl-2-thiouridine

✍ Scribed by A. Mal̵kiewicz; E. Sochacka; A.F. Sayed Ahmed; S. Yassin

Publisher
Elsevier Science
Year
1983
Tongue
French
Weight
283 KB
Volume
24
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

THE !'Q>!)IFI~:r) NUCLEOSIDLE FHO?l THE 11 W0BBL.s POSITIOlY )) OF WNAs. A.?faZkiewics', 3. Sochacka , A.F. Sayed Ahmed and S. Yassin' Institute of 3rganic 'Chemistry , 'I'echnical :Jniversity go-924 c&i , Lwirki 36, Poland Abstract:: he synthesis of 5-carboxymethyl.a:ninomethyluridifie isolated from i,ZN$CIY(B. subtilis)and its 2-thio analogue from t.l!NBLys(n. subtilis) have been described. The modified nuclessides located at the first; position of i-he anticodons of tH?JA 131-y and tRNALys from R, subtilis were ietersined 3s 5-carboxyme"Lhyl-aminome&yluridine(l)' and 5-cerboxymcthyloroinomethyl-2-~~hiouri:linej~)". The proof of structure was mainly based on the mass spectrometry anslysis of persilylated derivatives of isolate:1 compounds and yemarkabI.e rcsemblanse of their UV spectra to the respective spectral :iata of 5-methyiaminomethyluridize and 5-methylaminomethyl-2-thiourijine. Tt is noteworthy , that 5-methyl:%ainomethyluridine and 5-methylaminomethyl-2-thi.ourir!i.ne structurally are .fecarbo-

📜 SIMILAR VOLUMES

Modified components of RNA. The molecula
Modified components of RNA. The molecular and crystal structure of 5-carboxymethylaminomethyl-2-thiouridine (S2cmnm5U)
✍ Michał W. Wieczorek; Grzegorz D. Bujacz; Dorota A. Adamiak; Andrzej Małkiewicz; 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 690 KB

The structure of the title compound 1 has been determined by X-ray analysis. The following crystal data were found: orthorhombic, P2J2J.?1, a = 5.243(2), b = 24.864(4), and c = 37.083(6) A. Three molecules of the compound with four molecules of water are present in the independent part of the unit c

The protected derivatives of 5-methylami
The protected derivatives of 5-methylaminomethyl-2-thiouridine and 5-carbomethoxymethyl-2-thiouridine as components for the oligonucleotide synthesis
✍ A. Małkiewicz; E. Sochacka 📂 Article 📅 1983 🏛 Elsevier Science 🌐 French ⚖ 273 KB

The syntheses of protected derivatives of 5-methylaminomethyl-2-thiouridine(mnm5s2U)11 \_, IJ and 5-carbomethoxymethyl-2-thiouridine(mcm5s2U)13 as well as their unprotected 3'-phosphates 3, 15 have been described.

Photochemical removal of the tosyl group
Photochemical removal of the tosyl group from the 5′N position of 5′-aminopyrimidine nucleosides: syntheticapplications
✍ Wojciech Urjasz; Lech Celewicz 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 104 KB

The p-toluenesulfonyl (tosyl) group, an effective protector of the amine function of thymidine derivatives 2a and b, has proven to be photoremovable. This photoreaction was successfully used in the synthesis of new 5'-amino analogs of 3'-azido-3'-deoxythymidine (AZT), 6a and b. Selective photohydrol

ChemInform Abstract: Synthesis of Hydant
ChemInform Abstract: Synthesis of Hydantoin Nucleosides with Naphthylmethylene Substituents in the 5-Position.
✍ A. I. KHODAIR; EL-S. E. IBRAHIM 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 29 KB 👁 2 views

Synthesis of Hydantoin Nucleosides with Naphthylmethylene Substituents in the 5-Position. -A number of the title hydantoin nucleosides (cf. (V), (VIII); 15 examples) are synthesized and evaluated for their antiviral activity. None of these nucleosides displays any significant activity. -(KHODAIR, A