Acyl carbamate directing groups in nucleoside synthesis: Applications in the synthesis of 2′-deoxy-5-ethyl-4′-thiouridine
✍ Scribed by Sue Shaw-Ponter; Gail Mills; Mark Robertson; Roy D. Bostwick; George W. Hardy; Robert J. Young
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 203 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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Treatment of methyl 3,5-di-O-benzyl-2-deoxy-a,8-r>-erythro-pentofuranoside with a-toluenethiol and cont. hydrochloric acid gave 3,5-di-0-benzyl-2-deoxy-D-erythro-pentose dibenzyl dithioacetal (21). Mesylation of 21 and ring closure gave benzyl 3,S-di-O-benzyl-2-deoxy-l,4-dithio-a,P-L-threo-pentofura