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The Mitogenic Activity of Hepatocyte Growth Factor on Rat Hepatocytes Is Dependent upon Endogenous Transforming Growth Factor-α

✍ Scribed by Tomoaki Tomiya; Itsuro Ogata; Miho Yamaoka; Mikio Yanase; Yukiko Inoue; Kenji Fujiwara


Book ID
117022385
Publisher
American Society for Investigative Pathology
Year
2000
Tongue
English
Weight
378 KB
Volume
157
Category
Article
ISSN
0002-9440

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Hepatocyte growth factor and transforming growth factor-a are two well-known hepatomitogens for primary hepatocyte cultures. Here we report that these two growth factors also stimulate in uiuo DNA syntheses in normal, unoperated, adult rat liver after 24-hr continuous intraportal infusion. As determ