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Effects of protein kinase inhibitors on the mitogenic activity of human hepatocyte growth factor on rat hepatocytes in primary culture

✍ Scribed by Naokatu Arakaki; Shuichi Hirono; Shuichi Kawakami; Hirohito Tsubouchi; Takehisa Ishii; Hiroto Hara; Yasushi Daikuhara

Book ID
117055207
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
453 KB
Volume
185
Category
Article
ISSN
0006-291X

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The effect of recombinant human hepatocyte growth factor (h-rHGF), a potent mitogen for hepatocytes, was investigated in primary cultures of human hepatocytes. Here, we describe a series of experiments to investigate the kinetics of its mitogenic action, as well as its metabolic effects on cultured