✦ LIBER ✦

The microsomal hydroxylation of aniline mustard-d3 [n, n-di- (2- chloroethyl) - 2,4,6-trideuterioaniline]

✍ Scribed by P. B. Farmer; A. B. Foster; M. Jarman

Publisher: John Wiley and Sons
Year: 1975
Tongue: English
Weight: 450 KB
Volume: 2
Category: Article
ISSN: 1076-5174
DOI: 10.1002/bms.1200020207

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✦ Synopsis

The metabolism by rat liver microsomes of the 2,4,6-trideuterio derivative of aniline mustard [N,N-di-(2-chloroethyl)aniline] in admixture with unlabelled material, has been studied. The resulting p-hydroxy derivative was isolated and examined by mass spectrometry. The extent of migration of deuterium from the p-to the mposition, determined from the ratio of trideuteriated to dideuteriated product, was 46%, but the protium and deuterium forms were hydroxylated at the same rate (zero isotope effect).

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