Synthesis, characterization and cytotoxicity of some triarylbismuth(V) di(N-p-toluenesulfonyl) aminoacetates and the crystal structure of (4-CH3C6H4SO2NHCH2CO2)2Bi(C6H4Cl-4)3

✍ Scribed by Lin Yu; Yong-Qiang Ma; Guo-Cang Wang; Hai-Bin Song; Hong-Geng Wang; Jin-Shan Li; Jing-Rong Cui; Rui-Qing Wang

• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: English
• Weight: 108 KB
• Volume: 18
• Category: Article
• ISSN: 0268-2605
• DOI: 10.1002/aoc.609

✦ Synopsis

A series of triarylbismuth(V) di(N-p-toluenesulfonyl)aminoacetates with the formula (4-CH 3 C 6 H 4 SO 2 NHCH 2 CO 2 ) 2 BiAr 3 (Ar C 6 H 5 , 4-CH 3 C 6 H 4 , 4-ClC 6 H 4 , 4-BrC 6 H 4 ) were synthesized and characterized by elemental analysis, IR, 1 H NMR and mass spectra. The crystal structure of (4-CH 3 C 6 H 4 SO 2 NHCH 2 CO 2 ) 2 Bi(C 6 H 4 Cl-4) 3 was determined and shows the bismuth to exist in a distorted trigonal bipyramidal geometry. Four human neoplastic cell lines (HL-60, PC-3MIE8, BGC-823 and MDA-MB-435) were used to screen these compounds. The results indicate that these compounds at 10 µM show cytotoxicity.