The methyl-CpG binding protein MeCP2 is essential for embryonic development in the mouse
β Scribed by Tate, Peri; Skarnes, William; Bird, Adrian
- Book ID
- 109915204
- Publisher
- Nature Publishing Group
- Year
- 1996
- Tongue
- English
- Weight
- 549 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1061-4036
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Rett syndrome (RTT or RS) is a neurodevelopmental disorder and one of the most frequent genetic diseases in girls. Mutations of the MECP2 gene have been found in a variety of different RTT phenotypes. The MECP2 gene (Xq28) has been described in 1992. Up to now, 218 different mutations have been repo
DNA methylation at the promoter region of X-linked genes is associated with the maintenance of X inactivation in mammals. One of the methylated DNA binding proteins, MECP2, that binds to methylated bases in DNA is encoded by a gene (Mecp2) located on the mouse X Chromosome (Chr). To determine whethe
## Abstract Mutations in the MeCP2 gene cause Rett syndrome, a neurologic condition affecting primarily young girls. To gain insight into the normal function of MeCP2, we examined its temporal and spatial expression patterns, and immunoreactive prevalence, during late embryonic and perinatal brain
## Abstract The developmental pattern of expression of the G protein Ξ±~O~ subunit and GAP43 were compared by immunohistochemical staining of mouse embryos. Staining for Ξ±~O~ and GAP43 was identical and detected throughout the developing nervous system, and the antigens first appeared in neurons at