The X-linked methylated DNA binding protein,Mecp2, is subject to X inactivation in the mouse
✍ Scribed by D. A. Adler; N. A. Quaderi; S. D. M. Brown; V. M. Chapman; J. Moore; P. Tate; C. M. Disteche
- Publisher
- Springer-Verlag
- Year
- 1995
- Tongue
- English
- Weight
- 233 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0938-8990
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✦ Synopsis
DNA methylation at the promoter region of X-linked genes is associated with the maintenance of X inactivation in mammals. One of the methylated DNA binding proteins, MECP2, that binds to methylated bases in DNA is encoded by a gene (Mecp2) located on the mouse X Chromosome (Chr). To determine whether this gene was expressed from the inactive X Chr, and X-autosome translocation (T(X; 16) 16H) system in which expression from the Mecp2 allele on the inactive X Chr could be assayed was used. Results from these experiments indicate that Mecp2 is subject to X inactivation in mouse.