GO, a guanine nucleotide binding protein, is expressed during neurite extension in the embryonic mouse
✍ Scribed by C. J. Schmidt; M. Zubiaur; D. Valenzuela; E. J. Neer; U. C. Dräger
- Book ID
- 102909685
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 555 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0360-4012
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✦ Synopsis
Abstract
The developmental pattern of expression of the G protein α~O~ subunit and GAP43 were compared by immunohistochemical staining of mouse embryos. Staining for α~O~ and GAP43 was identical and detected throughout the developing nervous system, and the antigens first appeared in neurons at the beginning of neuronal differentiation. GAP43 and α~O~ were not detected in regions containing only neuroblasts. These observations suggest that α~O~ and GAP43 may not be required for the decision to pass from neuroblast to differentiated neuron, but may play a role in signal transduction during early neuronal development. © 1994 Wiley‐Liss, Inc.