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The metabolism of dibenz[b,f]-1,4-oxazepine (CR): In vivo hydroxylation of 10,11-dihydrodibenz[b,f]-1,4-oxazepin-11-(1OH)-one and the NIH shift

✍ Scribed by J. M. Harrison; R. J. Clarke; T. D. Inch; D. G. Upshall

Book ID
112658457
Publisher
Springer
Year
1978
Tongue
English
Weight
194 KB
Volume
34
Category
Article
ISSN
1420-682X

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πŸ“œ SIMILAR VOLUMES

The synthesis and chemistry of [11-14C]-
The synthesis and chemistry of [11-14C]-dibenz[b,f] [1,4]oxazepine
✍ J. M. Harrison; T. D. Inch; D. G. Upshall πŸ“‚ Article πŸ“… 1978 πŸ› John Wiley and Sons 🌐 French βš– 211 KB

## Abstract The synthesis of [11‐^14^C]‐dibenz[b,f][1,4]oxazepine 1 is described. Chromium trioxide – pyridine oxidation of 1 gives [11‐^14^C]‐10, 11‐dihydrodibenz [b,f][1,4] oxazepin‐11‐one 3 which on hydrolysis gives 2‐amino‐2′‐[^14^C]‐carboxydiphenylether 4. Hydrogenation of 1 affords [11‐^14^C]