The C1-C9 northern fragment of aurisides 12a was prepared in eight steps and 41% overall yield starting from Grieco's bicyclic lactone (þ)-4. The synthesis features a key stereoselective Meinwald reaction of the lithium enolate of alkyl propionate with the functionalized d-lactone 3.
The Meinwald Reaction of Alkyl Propionates. Synthesis of the C1—C9 Fragment of Aurisides.
✍ Scribed by Maria-Yolanda Rios; Francisco Velazquez; Horacio F. Olivo
- Book ID
- 101955569
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 134 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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