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Synthesis of the C1−C9 Fragment of Callipeltoside-A †

✍ Scribed by Velázquez, Francisco; Olivo, Horacio F.


Book ID
127388625
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
76 KB
Volume
2
Category
Article
ISSN
1523-7060

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Synthesis of a C1–C9 fragment of rhizoxi
✍ Richard J Davenport; Andrew C Regan 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 91 KB

A C1-C9 fragment of the antitumour macrolide rhizoxin has been synthesised. An Evans' asymmetric aldol reaction was used to set up the first two chiral centres, and an a,b-unsaturated d-lactone was then formed on the acyclic system by an intramolecular Wadsworth-Emmons reaction. Stereoselective hydr