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Synthesis of C1C8 and C9C24 fragments of (−)-discodermolide: use of asymmetric alkylation and stereoselective aldol reactions

✍ Scribed by Sandra A. Filla; Jinhua J. Song; Lihren Chen; Satoru Masamune

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
301 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis

The C1-C8 and C9--C24 fragments of (-)-discodermolide, the antipode of the marine natural product (+)discodermolide, have been synthesized with excellent stereoselectivities. These syntheses feature the utilization of the isoxazolidine-mediated asymmetric alkylation methodology and fragment-fragment coupling aldol reactions.

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