✦ LIBER ✦

Stereoselective synthesis of the C7C21 segment of epothilone A via asymmetric alkoxyallyl- and crotylboration

✍ Scribed by P.Veeraraghavan Ramachandran; Bodhuri Prabhudas; Debarshi Pratihar; J.Subash Chandra; M.Venkat Ram Reddy

Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 272 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(03)00748-2

No coin nor oath required. For personal study only.

✦ Synopsis

The synthesis of the C 7 C 21 fragment of epothilone A involving asymmetric alkoxyallyl-and crotylboration using a-pinene-derived reagents is described.

📜 SIMILAR VOLUMES

Stereoselective Synthesis of the C7—C21

Stereoselective Synthesis of the C7—C21 Segment of Epothilone A via Asymmetric Alkoxyallyl- and crotylboration.

✍ P. Veeraraghavan Ramachandran; Bodhuri Prabhudas; Debarshi Pratihar; J. Subash C 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 62 KB

Epoxide opening with acetylide for synth

Epoxide opening with acetylide for synthesis of epothilone A C7–21 segment

✍ Zhi-yu Liu; Chen-zhi Yu; Rui-Fang Wang; Gang Li 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 172 KB

A Chiral synthesis ofepothilone A C7-21 segment 2 is described using epoxide opening with acetylide for the construction of the C~2.~.~ cis double bond and a modified Wittig reaction tbr introduction of the thiazole side chain.

Synthetic studies directed towards epoth

Synthetic studies directed towards epothilone A: Enantioselective synthesis of a C7  C15 carboxaldehyde segment

✍ Panicker Bijoy; Mitchell A. Avery 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 183 KB

Enantioselective syntheses of a protected C7-C15 fragment of epothilone A is reported in ten manipulations in good overall yield. An alkynyl-aluminum induced opening of a chiral epoxide followed by reordering of functionality furnished the iodide 18. Chain elongation with N-propionyl-lS-(-)-2,10-cam

ChemInform Abstract: Epoxide Opening wit

ChemInform Abstract: Epoxide Opening with Acetylide for Synthesis of Epothilone A C7-21 Segment.

✍ Z. LIU; C. YU; R.-F. WANG; G. LI 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 37 KB 👁 2 views

Total synthesis of preswinholide A. 1. S

Total synthesis of preswinholide A. 1. Stereoselective synthesis of the C11C23 segment

✍ Kazuo Nagasawa; Isao Shimizu; Tadashi Nakata 📂 Article 📅 1996 🏛 Elsevier Science 🌐 French ⚖ 233 KB

Synthesis of the C(1)-C(9) segment of th

Synthesis of the C(1)-C(9) segment of the cytotoxic macrolides epothilon A and B

✍ Johann Mulzer; Andreas Mantoulidis 📂 Article 📅 1996 🏛 Elsevier Science 🌐 French ⚖ 213 KB

The C( 1)-C(9) segment 3 of the macrolides epothilon A and B 1, two new cytotoxic natural products, has been synthesized in a direct manner. Key steps in the synthesis are a stereoselective aldol reaction of 6 and 7 and a Brown allylation of 9.