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Epoxide opening with acetylide for synthesis of epothilone A C7–21 segment

✍ Scribed by Zhi-yu Liu; Chen-zhi Yu; Rui-Fang Wang; Gang Li

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
172 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

A Chiral synthesis ofepothilone A C7-21 segment 2 is described using epoxide opening with acetylide for the construction of the C~2.~.~ cis double bond and a modified Wittig reaction tbr introduction of the thiazole side chain.

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Synthetic studies directed towards epothilone A: Enantioselective synthesis of a C7  C15 carboxaldehyde segment
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