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Radical-induced Opening of Trisubstituted Epoxides: Application in the Synthesis of C1–C12 Segment of Epothilones

✍ Scribed by T.K Chakraborty; S Dutta

Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 557 KB
Volume: 39
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(97)10442-7

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✦ Synopsis

Disstereo-andregioselective opening ofa trisubstituted epoxy ketone atthemoresubstituted carbon using sanrarium(II) iodide presents an alternate approach to the C5-C7 afdol moiety with & hydroxyketoframework in the stereoselectivesynthesisof C1-C12 segmentof epothilones.

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