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Synthesis of the C1C9 segment of epothilons

✍ Scribed by Eckhard Claus; Axel Pahl; Peter G. Jones; Hartmut M. Meyer; Markus Kalesse

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
174 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

The CI-C9 segment of epothilons was generated by an aldol reaction between chiral aldehyde 3 and ethyl ketone 4. Removal of the TBS protecting groups and debenzylation generated spiro ketal 13 which was analyzed by X-ray crystallography.

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