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Stereoselective synthesis of C(1)–C(9) and C(11)–C(17)fragments of protomycinolide iv based on asymmetric pinacol-typerearrangement

✍ Scribed by Keisuke Suzuki; Katsuhiko Tomooka; Takashi Matsumoto; Eiji Katayama; Gen-ichi Tsuchihashi

Publisher: Elsevier Science
Year: 1985
Tongue: French
Weight: 271 KB
Volume: 26
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)89230-8

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✦ Synopsis

Two chiral intenediates, C(l)-C( 9) and C(llI-Cc171 portions of protomycinolide IV, were synthesized both from (Sl-ethyl lactate via asymmetric pinacoZ-type rearrangement folZowed b2 diastereoselective reactions on cc-methyl-B,y-unsaturated carbonyl compounds.

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