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The Maculatin peptides from the skin glands of the tree frog Litoria genimaculata: a comparison of the structures and antibacterial activities of Maculatin 1.1 and Caerin 1.1

✍ Scribed by Tomas Rozek; Russell J. Waugh; Simon T. Steinborner; John H. Bowie; Michael J. Tyler; John C. Wallace

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 84 KB
Volume: 4
Category: Article
ISSN: 1075-2617
DOI: 10.1002/(sici)1099-1387(199804)4:2<111::aid-psc134>3.0.co;2-8

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✦ Synopsis

Six peptides have been isolated and characterized from the dorsal glands of the tree frog Litoria genimaculata. One of these is the known hypotensive peptide caerulein; the others have been named maculatins. The amino acid sequences of the maculatin peptides have been determined using a combination of fast atom bombardment mass spectrometry and automated Edman sequencing. Four of the maculatin peptides show antibiotic activity, with maculatin 1.1 [GLFGVLAKVAAHVVPAIAEHF(NH 2 )] showing the most pronounced activity, particularly against Gram-positive organisms. Maculatin 1.1 resembles the known caerin 1 antibiotic peptides, except that four of the central amino acid residues (of the caerin 1 system) are missing in maculatin 1.1. A comparison of the antibiotic activity of maculatin 1.1 with those of caerin 1.1 is reported.

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