✦ LIBER ✦

A Comparison of the Positive- and Negative-ion Mass Spectra of Bio-active Peptides from the Dorsal Secretion of the Australian Red Tree Frog, Litoria rubella

✍ Scribed by Simon T. Steinborner; John H. Bowie

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 367 KB
Volume: 10
Category: Article
ISSN: 0951-4198
DOI: 10.1002/(sici)1097-0231(19960731)10:10<1243::aid-rcm639>3.0.co;2-i

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✦ Synopsis

The collision-induced tandem mass spectral data for MH' and [M -HI-ions from six bio-active peptides from Litoriu rubella are compared. Backbone cleavages of [M -HI-ions provide sequencing information for five of the peptides [e.g. Phe Pro 'lkp Leu (NH,) and pGlu Phe Pro 'lkp Leu (NH,)] and in these cases, the negative-ion spectra are as informative as the positive-ion spectra. Side-chain cleavages are also noted in these spectra. For example, (i) when 'lkp is present, the loss of C,H,N (129 u) competes with the backbone cleavages, and (ii) the [M -HI-ion of ne Glu Phe Phe Thr (NH,) undergoes facile side-chain fragmentation [loss of H,O (from Glu)

and MeCHO (from Thr)], but does not form any conventional backbone-cleavage ions.

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