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The macromolecular state of A-kinase anchoring protein

✍ Scribed by Trushar R. Patel; Donald J. Winzor

Book ID: 102372925
Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 201 KB
Volume: 25
Category: Article
ISSN: 0952-3499
DOI: 10.1002/jmr.1164

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✦ Synopsis

The amendment of the interpretation of recently published size‐exclusion chromatography (SEC) data for A‐kinase anchoring protein (AKAP12) on Sephacryl‐S400 has led to an increase in the estimated size of the supermolecular state from 840 to at least 6000 kDa. Although size‐exclusion chromatography has sufficed to demonstrate unequivocally the existence of this 190‐kDa scaffold protein in a supermolecular state, any quantitative estimate of the oligomer stoichiometry is shown to be precluded by failure of this empirical procedure to incorporate allowance for any deviation from globular shape—an important consideration in view of the extended structures exhibited by other extracellular matrix proteins. Copyright © 2011 John Wiley & Sons, Ltd.

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