Expression of a kinase anchoring protein 79 in the human fetal amygdala

✍ Scribed by Ulfig, Norbert; Setzer, Matthias

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 321 KB
• Volume: 46
• Category: Article
• ISSN: 1059-910X
• DOI: 10.1002/(sici)1097-0029(19990701)46:1<48::aid-jemt4>3.0.co;2-1

✦ Synopsis

The expression of AKAP (a kinase anchoring protein) 79 enriched in postsynaptic densities has been investigated in the human amygdaloid nuclei of the 8th gestational month. Nuclear specific diffuse and cellular immunostaining is observed. An outstanding feature of cellular immunostaining is the labelling of somata and dendritic trees in a manner that allows neuronal classification. Bipolar, multipolar, and pyramidal AKAP79-positive neurons are found throughout the amygdala; the highest packing density of immunostained neurons is seen within the central and lateral nucleus. Dense diffuse immunolabelling is observed in the lateral and accessory basal nucleus. The results indicate that AKAP79 is expressed in various neuronal types (projection as well as local circuit neurons). Diffuse staining does not always match with cellular labelling within a nucleus, thus, AKAP79 may be particularly enriched in dendrites in some nuclei. The widespread distribution of AKAP79 indicates its possible role in various amygdaloid circuitries; thus, AKAP79 does not seem to be restricted to definite functional systems in the 8th month.