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Comparative analysis of the expression of the extracellular matrix protein tenascin in normal human fetal, adult and tumor tissues

✍ Scribed by Pier Giorgio Natali; Maria Rita Nicotra; Aldo Bigotti; Claudio Botti; Patrizia Castellani; Anna Maria Risso; Luciano Zardi

Publisher
John Wiley and Sons
Year
1991
Tongue
French
Weight
755 KB
Volume
47
Category
Article
ISSN
0020-7136

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✦ Synopsis

Tenaxin (TN) is a high-molecular-mass oligomeric glycoprotein of the extracellular matrix (ECM) endowed with a programmed expression in embryonic life and a neoexpression in the interstitium of some malignancies. Using monoclonal antibodies (MAbs) which identify human tenascin, we have conducted an extensive immunohistochemical analysis of TN expression in normal fetal and adult human tissues as well as in a wide variety of human tumors. Results of this study demonstrate that TN (I) is detectable in embryonic and fetal tissues at least from the 10th week of gestation;

(2) is present in the interstitium of a variety of adult tissues of different embryonic origin; (3) may be neo-expressed in the stroma of benign and malignant tumors; (4) has the ability to accumulate in a highly variable manner in the ECM of tumors of the same and of different histotypes.

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