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The locus for apolipoprotein CII is closely linked to the apolipoprotein E locus on chromosome 19 in man

✍ Scribed by Ola Myklebost; Sissel Rogne; Bjørnar Olaisen; Tobias Gedde-Dahl; Hans Prydz

Publisher
Springer
Year
1984
Tongue
English
Weight
362 KB
Volume
67
Category
Article
ISSN
0340-6717

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✦ Synopsis

We have demonstrated close linkage between the genes for apolipoprotein E (apoE) and apolipoprotein CII (apoCII). Families segregating for apoE protein variants were screened for a DNA restriction fragment length polymorphism close to the apoCII gene by using an apoCII cDNA clone. The maximum lod score is 4.52 (sexes combined) at a recombination frequency of zero. Given linkage, it may be assumed that no recombinations have happened in altogether 33 observed meioses. It is therefore evident that the apoCII gene is situated on chromosome 19, close to the apoE gene.

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