Myotonic dystrophy is associated with disturbances in the insulin response, possibly due to an abnormality of the insulin receptor. Both the myotonic dystrophy (DM) and insulin receptor (INSR) genes are on chromosome 19. Using a cloned gene probe for INSR, we have studied its linkage relationships w
Linkage relationships of the gene for apolipoprotein CII with loci on chromosome 19
β Scribed by J. A. Donald; S. C. Wallis; A. Kessling; P. Tippett; E. B. Robson; S. Ball; K. E. Davies; P. Scambler; K. Berg; A. Heiberg; R. Williamson; S. E. Humphries
- Publisher
- Springer
- Year
- 1985
- Tongue
- English
- Weight
- 452 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0340-6717
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We have demonstrated close linkage between the genes for apolipoprotein E (apoE) and apolipoprotein CII (apoCII). Families segregating for apoE protein variants were screened for a DNA restriction fragment length polymorphism close to the apoCII gene by using an apoCII cDNA clone. The maximum lod sc
We have isolated a cDNA clone for apolipoprotein CI and a genomic clone for apolipoprotein E, and by hybridisation and mapping experiments found the gene for apoCI to be located on the genomic apoE clone. The distance between the loci was 4.3 kb.
The genes encoding apolipoproteins CI, CII, and E have been previously localized to chromosome 19. By use of rodent-human hybrid cell lines containing translocations of chromosome 19 we have now mapped these three genes to the region 19p13-19q13 and most probably 19p13-19cen. The clustering of APOC1