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Localization of genes encoding apolipoproteins CI, CII, and E to the p13→cen region of human chromosome 19

✍ Scribed by J. Scott; T. J. Knott; D. J. Shaw; J. D. Brook

Publisher
Springer
Year
1985
Tongue
English
Weight
328 KB
Volume
71
Category
Article
ISSN
0340-6717

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✦ Synopsis

The genes encoding apolipoproteins CI, CII, and E have been previously localized to chromosome 19. By use of rodent-human hybrid cell lines containing translocations of chromosome 19 we have now mapped these three genes to the region 19p13-19q13 and most probably 19p13-19cen. The clustering of APOC1, APOC2, and APOE must reflect their common evolutionary background and suggests that they may be coordinately regulated. Polymorphisms detected for any one gene will be useful for inheritance studies of all three.

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