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The involvement of arachidonic acid and metabolites in the neurotoxicity of the prion peptide 106–126

✍ Scribed by Leanne R. Stewart; Anthony R. White; Michael F. Jobling; Fran Maher; B.Elise Needham; James M. Thyer; Steven J. Collins; Roberto Cappai

Book ID
117411612
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
181 KB
Volume
21
Category
Article
ISSN
0197-4580

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✍ Leanne R. Stewart; Anthony R. White; Michael F. Jobling; B. Elise Needham; Fran 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 319 KB

## Abstract Transmissible spongiform encephalopathies are characterised by the transformation of the normal cellular prion protein (PrP^C^) into an abnormal isoform (PrP^TSE^). Previous studies have shown that N‐methyl‐D‐aspartate (NMDA) receptor antagonists can inhibit glutathione depletion and ne