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Copper and Zinc Binding Modulates the Aggregation and Neurotoxic Properties of the Prion Peptide PrP106−126 †

✍ Scribed by Jobling, Michael F.; Huang, Xudong; Stewart, Leanne R.; Barnham, Kevin J.; Curtain, Cyril; Volitakis, Irene; Perugini, Matthew; White, Anthony R.; Cherny, Robert A.; Masters, Colin L.; Barrow, Colin J.; Collins, Steven J.; Bush, Ashley I.; Cappai, Roberto


Book ID
120434648
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
283 KB
Volume
40
Category
Article
ISSN
0006-2960

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## Abstract __The human prion protein fragment PrP__~__106–126__~ __is a highly fibrillogenic peptide, resistant to proteinases and toxic to neurons; it derives from the normal prion protein (PrP__^__C__^__), with which it can interact, thus inhibiting its superoxide dismutase‐like activity. The sa