✦ LIBER ✦

The interleukin-1 family of molecules

✍ Scribed by Anthony C. Allison

Publisher: John Wiley and Sons
Year: 1985
Tongue: English
Weight: 518 KB
Volume: 3
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.950030608

No coin nor oath required. For personal study only.

✦ Synopsis

Two types of interleukin I (IL-la and IL-IB) have been defined by purifying the molecules from activated human peripheral blood cells, followed by cloning and expressing the molecules in Escherichia coli. Both types of IL-1 stimulate proliferation and diferentiation of T-and B-lymphocytes and induce cartilage proteoglycan degradation but d y e r in other properties. For example, demineralization and appears to be a major mediator in the pathogenesis of joint erosion in rheumatoid arthritis. Synthetic adjuvants elicit the production of IL-1 separate from endogenous pyrogen, and this property is required for the new generation of vaccines based on antigens produced by recombinant D N A technology.

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