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The interaction of tetrahydroisoquinoline derivatives with antinociceptive action of morphine and oxotremorine in mice

✍ Scribed by J. Vetulani; F. Pavone; B. Przewłocka; V. Borghi; I. Nalepa

Book ID
106206557
Publisher
Springer
Year
2003
Tongue
English
Weight
275 KB
Volume
110
Category
Article
ISSN
1435-1463

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Effect of midbrain raphe lesion on the antinociceptive action of morphine and other analgesics in rats
✍ R. Samanin; D. Ghezzi; C. Mauron; L. Valzelli 📂 Article 📅 1973 🏛 Springer 🌐 English ⚖ 267 KB

The antinociceptive action of several analgesics was studied by two methods: the hot-plate and the tail compression tests. Lesions of the midbrain raphe, which produce a marked depletion of serotonin in the forebrain, antagonize the analgesic effect of morphine but not that of methadone, meperidine