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SEX DIFFERENCES AND THE EFFECT OF GONADECTOMY ON MORPHINE-INDUCED ANTINOCICEPTION AND DEPENDENCE IN RATS AND MICE

✍ Scribed by B. H. Ali; S. I. Sharif; A. Elkadi


Book ID
108936589
Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
315 KB
Volume
22
Category
Article
ISSN
0305-1870

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✍ Marianne Ekblom; Marie GΓ₯rdmark; Margareta Hammarlund-Udenaes πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 555 KB

In this study the pharmacokinetics and pharmacodynamics of morphine-3-glucuronide (M3G) were investigated in rats after i.v. administration as a bolus dose (86.7 pmol kg-I) and as a constant rate infusion (2.9 pmol h-') over 5 days. After the bolus dose, the clearance (Cl) was 12.1 ~0.6mlmin-\*\*kg,