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The insulin-like growth factor pathway as a target for cancer therapy

✍ Scribed by Iker López-Calderero; Elizabeth Sánchez Chávez; Rocío García-Carbonero

Publisher
Springer Milan
Year
2010
Tongue
Spanish
Weight
702 KB
Volume
12
Category
Article
ISSN
1699-048X

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The crucial step of folding of recombinant proteins presents serious challenges to obtaining the native structure. This problem is exemplified by insulin-like growth factor (IGF)-I which when refolded in vitro produces the native three-disulfide structure, an alternative structure with mispaired dis