The insulin-like growth factor system as a target in breast cancer
โ Scribed by Douglas Yee
- Publisher
- Springer US
- Year
- 1994
- Tongue
- English
- Weight
- 1000 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0167-6806
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In the current study the authors have investigated whether human primary breast cancer specimens contain insulin-like growth factor-1 (IGF-1) receptors (IGF-1-R) or IGF-1-like activities. Simultaneously, epidermal growth factor (EGF) receptors (EGF-R) and cytosolic estrogen receptor (ER), progestero
Consideration of existing data regarding clinical and biochemical risk factors for the development of breast cancer leads to the hypothesis that enhanced insulin-like growth factor I (IGF-I) activity plays a significant role in the development of this disease. Abnormal IGF-l activity may be related
Insulin-like growth factor-I (IGF-I) has mitogenic and antiapoptotic effects on breast cancer cells. Epidemiologic studies have shown that high plasma levels of IGF-I and low levels of IGF binding protein (BP)-3 are associated with increased risk of breast cancer in premenopausal women. The actions