✦ LIBER ✦

Insulin resistance, insulin-like growth factor I and breast cancer: A hypothesis

✍ Scribed by Ralph R. Kazer

Publisher: John Wiley and Sons
Year: 1995
Tongue: French
Weight: 591 KB
Volume: 62
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910620408

No coin nor oath required. For personal study only.

✦ Synopsis

Consideration of existing data regarding clinical and biochemical risk factors for the development of breast cancer leads to the hypothesis that enhanced insulin-like growth factor I (IGF-I) activity plays a significant role in the development of this disease. Abnormal IGF-l activity may be related to events occurring prenatally, during puberty, or during adult life. Insulin resistance, a common feature in populations characterized by high caloric intake, may result in the amplification of IGF-I action at the tissue level by altering serum concentrations of IGF-I binding proteins. Several approaches toward testing the hypothesis are proposed, and potential opportunities for clinical application are described.

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