Cirrhosis is characterized by paradoxical growth hormone secretion in response to glucose and insulin infusion. To ascertain whether this abnormality contributes to insulin resistance, euglycemic hyperinsulinemic glucose clamps were performed on six patients with cirrhosis and six normal control subjects. Each patient with cirrhosis underwent two clamps in random order, a clamp with somatostatin (250 pg/hr) together with insulin and glucagon replacement, and a control clamp without somatostatin. The normal subjects underwent the control clamp only. During the control clamp, growth hormone levels were considerably higher in the patients with cirrhosis (6.1 f 0.4 vs. 0.5 f 0.4 mU/L, p < 0.02), and glucose uptake was considerably lower (3.29 & 0.56 vs. 9.52 f 1.14 mg/kg/min, p < 0.001). Indirect calorimetry indicated that the defect was accounted for by lower nonoxidative glucose disposal (1.23 f 0.45 vs. 6.00 f 0.73, p < 0.001). Peripheral glucose uptake, exemplified by forearm glucose uptake (0.27 f 0.04 vs. 1.22 f 0.42 mg/100 ml/min, p < 0.021, and calculated insulin sensitivity (24 f 8 vs. 114 f 20 pl/kg/min per mUL) were particularly diminished. In the patients with cirrhosis somatostatin suppressed growth hormone levels (6.1 -t 1.2 to 1.2 f 0.4 mU/L, p < 0.05). However, no significant changes occurred in whole-body glucose uptake (3.29 f 0.56 vs 3.01 f 0.54 mg/kg/min), forearm glucose uptake (0.27 -C 0.04 vs 0.30 & 0.01 mg/100 ml/min) or insulin sensitivity (24 & 8 vs. 35 & 10 pl/kg/min/mU/L, p = 0.42). Suppression of abnormal growth hormone secretion by somatostatin over 5 hr does not alter insulin sensitivity or glucose uptake in cirrhosis. (HEPATOLOGY 1994;19:322-328.) Cirrhosis is characterized by high growth hormone levels, which fail to decrease and often paradoxically increase after administration of glucose or insulin (1-4). The cause of the higher growth hormone levels remains uncertain. The metabolic clearance rate of growth hormone has been found to be diminished in some