✦ LIBER ✦

Growth hormone, insulin-like growth factor I, and motoneuron size

✍ Scribed by Chen, L. ;Lund, P. K. ;Burgess, S. B. ;Rudisch, B. E. ;McIlwain, D. L.

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 120 KB
Volume: 32
Category: Article
ISSN: 0022-3034
DOI: 10.1002/(sici)1097-4695(199702)32:2<202::aid-neu5>3.0.co;2-c

No coin nor oath required. For personal study only.

✦ Synopsis

In this study we asked whether their normal size relationships were preserved in the growth hormone (GH) and one of its key mediators, transgenic mice. In addition, spinal cord and brain insulin-like growth factor I (IGF-I), influence spinal weights were significantly increased in both types of motoneuron size in conjunction with whole body size. transgenic animal. We conclude that GH can regulate We present evidence that GH has such a role, possibly motoneuron, central nervous system, and body size without the mediation of IGF-I. Both lumbar motoneuin the same animal, and that IGF-I can mimic the efron and body size were found to be increased relative fects of GH on at least two of these three parameters. to littermate controls in transgenic mice overexpressing

📜 SIMILAR VOLUMES

Growth retardation in Down syndrome in r

Growth retardation in Down syndrome in relation to insulin-like growth factors and growth hormone

✍ Annerén, Göran ;Gustavson, Karl-Henrik ;Sara, Vicki R. ;Tuvemo, Torsten 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 414 KB 👁 2 views

Growth retardation is a cardinal characteristic of Down syndrome (DS). It is most pronounced from the age of 6 months, when growth starts to become growth hormone (GH) regulated. DS children have normal serum levels of GH. GH regulates the production of insulin-like growth factors (IGFs), which act

Serum insulin-like growth factor-I and b

Serum insulin-like growth factor-I and breast cancer

✍ Paolo Toniolo; Peter F. Bruning; Arslan Akhmedkhanov; Johannes M.G. Bonfrer; Kar 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 French ⚖ 57 KB 👁 1 views

Insulin-like growth factor family in mal

Insulin-like growth factor family in malignant haemangiopericytomas: the expression and role of insulin-like growth factor I receptor

✍ Paveli?, Kre?imir; Paveli?, Zlatko P.; Cabrijan, Tomislav; Karner, Ivan; Samar?i 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 235 KB 👁 2 views

Haemangiopericytoma is a rare soft tissue tumour originating from the contractile pericapillary cells. Relatively little is known about its molecular pathogenesis. To address this issue, the insulin-like growth factor family (IGFs) was analysed in 19 tumours collected from a human tumour bank networ

Insulin-like growth factor-I mediates os

Insulin-like growth factor-I mediates osteoclast-like cell formation stimulated by parathyroid hormone

✍ Hiroshi Kaji; Toshitsugu Sugimoto; Masanori Kanatani; Katsuhito Nishiyama; Masam 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 173 KB 👁 1 views

There have been several lines of evidence that parathyroid hormone (PTH) stimulates production of insulinlike growth factor I (IGF-I) in bone and that IGF-I stimulates osteoclast formation. Thus, the present study was performed to clarify the possible role of IGF-I in PTH-stimulated osteoclastlike c

Serum insulin-like growth factor-I, insu

Serum insulin-like growth factor-I, insulin-like growth factor binding protein-3, and the pubertal growth spurt in the female rhesus monkey

✍ Stanley J. Ulijaszek 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 179 KB 👁 1 views

Free insulin-like growth factor-I and br

Free insulin-like growth factor-I and breast cancer risk

✍ Benjamin D.L. Li; M. Javad Khosravi; Hans J. Berkel; Anastasia Diamandi; Mark A. 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 French ⚖ 56 KB 👁 1 views

Insulin-like growth factor-I (IGF-I) has mitogenic and antiapoptotic effects on breast cancer cells. Epidemiologic studies have shown that high plasma levels of IGF-I and low levels of IGF binding protein (BP)-3 are associated with increased risk of breast cancer in premenopausal women. The actions