Targeting insulin-like growth factor type 1 receptor in cancer therapy
β Scribed by Francesco Atzori; Tiffany A. Traina; Maria Teresa Ionta; Bruno Massidda
- Publisher
- Springer-Verlag
- Year
- 2009
- Tongue
- English
- Weight
- 326 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1776-2596
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In the current study the authors have investigated whether human primary breast cancer specimens contain insulin-like growth factor-1 (IGF-1) receptors (IGF-1-R) or IGF-1-like activities. Simultaneously, epidermal growth factor (EGF) receptors (EGF-R) and cytosolic estrogen receptor (ER), progestero
## Abstract Aberrations of the Insulinβlike Growth Factor (IGF) system have been found in association with a variety of cancer types. The potential role of IGF1R has been postulated in a small subset of GISTs, but until now the implications of its aberrations have not been defined. The aim of the s