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Effect of type 1 insulin-like growth factor receptor targeted therapy on chemotherapy in human cancer and the mechanisms involved

✍ Scribed by Alyse Hopkins; Philip J. Crowe; Jia-Lin Yang


Publisher
Springer-Verlag
Year
2010
Tongue
English
Weight
535 KB
Volume
136
Category
Article
ISSN
1432-1335

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## Abstract Interaction of insulin‐like growth factor receptor I (IGF‐IR) with its ligands has been reported to induce cell proliferation, transformation and blockade of cell apoptotic functions. IGF‐IR is overexpressed on numerous tumor cell types and its blockade could be of importance for anti‐c