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The initiation of the autoimmune response in multiple sclerosis

✍ Scribed by Silva Markovic-Plese; Clemencia Pinilla; Roland Martin


Book ID
118432132
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
238 KB
Volume
106
Category
Article
ISSN
0303-8467

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## Abstract TCR degeneracy may facilitate self‐reactive T cell activation and the initiation of an autoimmune response in multiple sclerosis (MS). MHC class II alleles of the DR2 haplotype DR2a (DRB5\*0101) and DR2b (DRB1\*1501) are associated with an increased risk for MS in Caucasian populations.

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