Degenerate TCR recognition and dual DR2
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Xin Zhang; Yunan Tang; Danuta Sujkowska; Jinzhao Wang; Vinod Ramgolam; Mireia So
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Article
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2008
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John Wiley and Sons
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English
β 456 KB
π 1 views
## Abstract TCR degeneracy may facilitate selfβreactive T cell activation and the initiation of an autoimmune response in multiple sclerosis (MS). MHC classβII alleles of the DR2 haplotype DR2a (DRB5\*0101) and DR2b (DRB1\*1501) are associated with an increased risk for MS in Caucasian populations.