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High level of cross-reactivity in influenza virus hemagglutinin-specific CD4+ T-cell response: Implications for the initiation of autoimmune response in multiple sclerosis

✍ Scribed by Silva Markovic-Plese; Bernhard Hemmer; Yingdong Zhao; Richard Simon; Clemencia Pinilla; Roland Martin

Book ID: 113729680
Publisher: Elsevier Science
Year: 2005
Tongue: English
Weight: 143 KB
Volume: 169
Category: Article
ISSN: 0165-5728
DOI: 10.1016/j.jneuroim.2005.07.014

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## Abstract TCR degeneracy may facilitate self‐reactive T cell activation and the initiation of an autoimmune response in multiple sclerosis (MS). MHC class II alleles of the DR2 haplotype DR2a (DRB5\*0101) and DR2b (DRB1\*1501) are associated with an increased risk for MS in Caucasian populations.