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The initial rate of change in distribution volume is the sum of intercompartmental clearances

โœ Scribed by Michael J. Avram; Thomas K. Henthorn; Colin A. Shanks; Tom C. Krejcie

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
175 KB
Volume
75
Category
Article
ISSN
0022-3549

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Area-based estimation of the initial vol
Area-based estimation of the initial volume of distribution and elimination rate constant following intravenous bolus injection
โœ Soo Peang Khor; Stephen L. Johnson; Michael Mayersohn ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 758 KB

We evaluate here an area term, the area under the rate of change of concentration-time curve (AURC), which allows the determination of the initial or central volume of distribution (V1). It has previously been shown that AURC is equal to the sum of the coefficients of a multiexponential equation and