Area-based estimation of the initial vol
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Soo Peang Khor; Stephen L. Johnson; Michael Mayersohn
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Article
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1991
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John Wiley and Sons
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English
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We evaluate here an area term, the area under the rate of change of concentration-time curve (AURC), which allows the determination of the initial or central volume of distribution (V1). It has previously been shown that AURC is equal to the sum of the coefficients of a multiexponential equation and