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The inhibitory effect of cyclic AMP on phosphatidylinositol kinase is not mediated by the cAMP dependent protein kinase

✍ Scribed by John J. O'Shea; Carlos A. Suárez-Quian; Richard A. Swank; Richard D. Klausner


Book ID
115760282
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
443 KB
Volume
146
Category
Article
ISSN
0006-291X

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Extracts obtained from rat hepatocytes incubated with saline, glucagon or insulin were electrophoresed on polyacrylamide gels and then assayed for cyclic (3H)AMP binding capacity. Analysis of the binding patterns demonstrated that glucagon dissociated a holoenzyme of cyclic AMP-dependent protein kin