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The influence of δ9-Tetrahydrocannabinol on intraocular pressure in the anaesthetized cat

✍ Scribed by H. C. Innemee; A. J. M. Hermans; P. A. Zwieten

Publisher
Springer-Verlag
Year
1980
Tongue
English
Weight
325 KB
Volume
48
Category
Article
ISSN
0012-4486

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✦ Synopsis

A9-Tetrahydrocannabinol (•9-THC) was injected both intravenously and into the brain stem via the left vertebral artery. Contrary to results obtained with clonidine, neither the fall in intraocular pressure (IOP), nor the arterial hypotension induced by A9-THC, were enhanced after the 'central' administration of the drug. For clonidine, a central mechanism underlying the ocular hypotensive effect has recently been proposed. This suggestion is based upon the enhanced fall in IOP after 'central' administration of clonidine. The pontomedullary area is considered to be the main initial target of this drug. Obviously, the IOP-lavering mechanism of A9-THC is different from that of clonidine.

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