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Δ9-tetrahydrocannabinol induced inhibition of predatory aggression in the rat

✍ Scribed by M. Marlyne Kilbey; J. Will Moore; Margaret Hall

Publisher
Springer
Year
1973
Tongue
English
Weight
626 KB
Volume
31
Category
Article
ISSN
0033-3158

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✦ Synopsis

gg-tetrahydrocannabinol inhibits predatory aggression in rats. Increases in the degree of inhibition are obtained with increasing dosages of the drug. Although sex and strain of the subjects varied nonsystematically, inhibition of predatory aggression uniformly was found to be dose related. Readministration of zJg-tetrahydrocannabinol did not effect motor activity measures at dose levels which inhibit aggression. Administration of d 9-tetrahydrocannabinol increases whole brain serotonin, while norepinepherine is largely unaffected, indicating that the anti-aggressive effect may be mediated, in part, by serotonergic mechanisms.

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