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The influence of clonidine on intraocular pressure

✍ Scribed by H. C. Innemee; P. A. Zwieten

Publisher
Springer-Verlag
Year
1979
Tongue
English
Weight
221 KB
Volume
46
Category
Article
ISSN
0012-4486

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✦ Synopsis

In order to study the influence of clonidine on intraocular pressure (IOP), the drug was administered via different routes. The experiments were performed on chloraloseanaesthetized cats. The rise in lOP observed after administration of clonidine into the external carotid arteries was subjected to a pharmacological analysis. Our experiments suggest that the increase in lOP is due to the contraction of eyelids and extraocular muscles, mediated by the influence of clonidine on a-adrenoceptors.

The lOP-lowering effect of clonidine was more pronounced after its infusion into the left vertebral artery than after its intravenous injection. This difference would suggest that the clonidine-induced decrease in lOP may be mediated via a central mechanism.

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