The influence of N-protected amino acid residues on the cis/trans isomerism of proline moieties in peptides
β Scribed by Wolfgang Voelter; Oskar Oster
- Publisher
- John Wiley and Sons
- Year
- 1973
- Tongue
- English
- Weight
- 141 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0749-1581
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β¦ Synopsis
Abstract
^13^C NMR spectroscopy is an excellent tool for studying the influence of Nβprotecting groups on the cis/trans isomerism of proline residues in proline peptides. This communication demonstrates the usefulness of ^13^C NMR spectroscopy in investigating conformational problems in protein and peptide chemistry.
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The stability and kinetics of unfolding and refolding of the P167T mutant of the TEM-1 p-lactamase have been investigated as a function of guanidine hydrochloride concentration. The activity of the mutant enzyme was not significantly modified, which strongly suggests that the Glu166Thr167 peptide bo
## Abstract Several Nβprotected peptide amides, containing two aromatic residues spaced by one glycyl residue, have been enzymatically synthesized starting from PβArβOH and HβGlyβArβNH~2~ (P is the protecting group and Ar is the aromatic residue) and using Ξ±βchymotrypsin as the catalyst for the cou